A new weight loss mechanism could “fool” The body believes that it has played sports, thanks to a molecule that reduces appetite and could become a secret weapon against obesity.
Mechanism by which you lose weight without physical exercise, even when you sleep naturallytensenet blog
Burning calories is not the only way in which physical exercises contribute to weight loss. Researchers at Stanford and Baylor College of Medicine discovered how a naturally produced molecule after intense effort-lake-phe-acts on the brain to diminish the feeling of hunger. If it were artificially synthesized, it could activate the same mechanism, stimulating the decrease in appetite and fat loss even without effective physical effort.
In this article you will find out what the experiments on mice have shown, how to compare the lake-phe effect with popular drugs such as Ozemmpic, and why The recent discovery published in Nature Metabolism could open the way to new treatments against obesity.
How Lac-Phe acts, the molecule that reduces appetite after exercise
Scientists found that, after the effort, the blood of the mice was flooded by a metabolite called Lac-Phe. In the brain, this molecule seems to block an “trigger” neuronally responsible for triggering the feeling of hunger. Discovery suggests a possibility “Extremely interesting”says medical researcher Yong Xu, from Baylor: In the future, innovative drugs could exploit this natural mechanism to help control weight.
It would not be something unprecedented. The active ingredient in popular drugs such as Ozempic was initially created to mimic a natural hormone that regulates blood sugar and sugar cravings.
“This discovery is important because it shows how a naturally produced molecule can influence appetite, interacting with a key region of the brain that regulates hunger and body weight”Explains the biochemist Jonathan Long, from Stanford.
The effects of lake-phe in humans: sport and molecule that reduces abdominal fat
Although not all the results obtained on mice can be applied immediately to humans, after identifying the lake-phe in 2022, subsequent studies have confirmed that the same metabolite grows in humans after physical exertion.
A recent endurance training study even showed that people who had higher levels of lake after sport lost more abdominal fat.
Now, researchers continue experiments to understand, at the molecular level, how this molecule acts and if it could be the key to new treatments against obesity.
The laboratory experiments confirmed the effect of the molecule: mice unable to produce lake more after sport, while the obese to whom this compound was given intravenously, lost weight and fat and improved blood sugar control.
How to inhibit the lake-phe neurons that trigger the feeling of hunger
“Understanding how lake-phe acts is essential to develop similar compounds to help people lose weight.”explains neurologist Yang He, from Baylor.
The researchers investigated the brain, the area that regulates appetite and food behaviors. The team analyzed two types of brain cells in mice:
AGRP neurons, which produce a protein that stimulate hunger in the hypothalamus and inhibit the activity of PVH neurons.
PVH neurons, responsible for reducing the feeling of hunger and controlling.
When the activity of the AGRP neurons is blocked, PVH neurons take control and reduce the appetite. Lac-phe seems to act exactly: inhibits AGRP neurons, contributing to decreased appetite.
If Lac-Phe works the same in humans, a drug based on its mechanism could mimic the effect of the metabolite, inhibiting AGRP neurons and thus reducing appetite.
Lac-phe: from laboratory to future treatments for obesity
Of course, there is much work to work until this possibility could become a reality. Research on the lake is only at the beginning, but current discoveries open the way to a new generation of obesity treatments and eating disorders. The fact that a molecule produced naturally by the body after sport can reduce the appetite and support weight loss offers an extremely promising perspective.
Although no one still talks about a “Minor treatment” To replace physical exercises, scientists believe that Lac-Phe could one day be the key to innovative therapies for appetite control and maintaining a healthy weight.
